Double Jeopardy: How Soluble P-Selectin Activates Leukocytes in Peripheral Arterial Occlusive Disease

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Double jeopardy: how soluble P-selectin activates leukocytes in peripheral arterial occlusive disease.

In this issue of Circulation Research, Woollard et al identify a critical role of pathologically elevated levels of soluble P-selectin (sP-selectin) found in the plasma of patients with peripheral arterial occlusive disease (PAOD) that promotes the activation of neutrophils and induces their adhesion to fibrinogen and platelet monolayers.1 P-selectin is an inflammatory adhesion molecule express...

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How Soluble P-Selectin Activates Leukocytes in Peripheral Arterial Occlusive Disease

In this issue of Circulation Research, Woollard et al identify a critical role of pathologically elevated levels of soluble P-selectin (sP-selectin) found in the plasma of patients with peripheral arterial occlusive disease (PAOD) that promotes the activation of neutrophils and induces their adhesion to fibrinogen and platelet monolayers.1 P-selectin is an inflammatory adhesion molecule express...

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Raised plasma soluble P-selectin in peripheral arterial occlusive disease enhances leukocyte adhesion.

Raised levels of soluble P-selectin (sP-selectin) have been reported in the plasma of patients with vascular diseases; however, the functional importance of this ligand remains unclear. In this study we have examined a potential role for plasma sP-selectin in regulating neutrophil adhesion in patients with peripheral arterial occlusive disease (PAOD). Patients with PAOD had significantly higher...

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Peripheral Arterial Occlusive Disease

• Objective: To review the evaluation and treatment of patients with peripheral arterial occlusive disease

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Studies in Peripheral Arterial Occlusive Disease

A controlled clinical-pathologic study of peripheral arteriosclerotic gangrene is reported in which all amputated specimens were examined by a special technic of injection and dissection of the arteries. The type of patient in whom gangrene usually develops is defined. The effect of various clinical and pathologic conditions on the degree of arterial insufficiency is discussed from the viewpoin...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 2005

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.0000200409.65882.14